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Fabrication and characterization of a fully integrated microdevice for in-vitro single cell assays
C. Collini, E. Morganti, R. Cunaccia, L. Odorizzi, C. Ress, and L. Lorenzelli (1), A. De Toni, G. Marinaro (2), M. Borgo (3), M. Maschietto (4), (1) FBK-BIOMEMS Unit, via Sommarive 18, 38123 Povo – TN – Italy, (2)Dipartimento di Ingegneria dell’informazione –University of Padova – 35131 Padova – Italy, (3) BioSiLab, 38068 Rovereto – TN – Italy
This work presents the microfabrication and preliminary characterization of a fully integrated microdevice for in-vitro single cell assays. This technological platform combines IDEs and MEA-based modules for cell addressed delivery of bio-functionalized nano/microparticles and single cell electroporation respectively.
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The Hind Sight of Nanotechnology
Suman Lahiri, Mamta Shah, L M College of Pharmacy
Nanotechnology addresses manipulation and study of structures and devices with length scales in the 1- to 100-nanometers range. Market growing upto 1 to 2.95 trillion $ by 2015, projects nanotubes to cross US$5 billion by the year 2012. In view of the toxicity that can be posed by it serious problems can threaten to neutralize the gains of nanotechnology.
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Modular Glass Chip System for the Acquisition of the Electric Activity and Physiological Parameters of Differentiated Stem Cells
P. J. Koester, J. Sakowski, S. M. Buehler, C. Tautorat, H. Altrichter, W. Baumann and J. Gimsa,
University of Rostock
The EU chemical policy REACH, effective on June 2007, regulates the registration, evaluation and authorization of chemicals. Investigations on the effects of neurotoxic and developmental-neurotoxic substances are required by European and US-American test guidelines. However, at the moment these tests are based on animal experiments contradicting society claims to abolish animal experiments and to implement the 3R-principle. The resulting problem is… How to pair REACH and the 3Rs?
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The Regulated Gas Medium with a Set of Nanoparticles Generated by the Solid Fuel Composition as a Method for Producing Ecovegetables
Alexandre V. Vakhrouchev and Valery B. Golubchikov,
Izhevsk State University, Ltd. “Nord”
New biotechnology involving nanoparticles for the production of ecologically pure vegetables in greenhouses has described. The main feature of the method is the generation of a special controlled gas medium containing nanoparticles of the main macro- and microelements, which freely penetrate into the foliage and stems of crops providing their metabolic activity. The source of the gas medium is the products of self-spreading high-temperature synthesis.
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Gold Coated Magnetic Nanoparticles for Specific Separation and Detection of Oligonucleotide Sequences and Proteins
Pedro Quaresma, Ricardo Franco, Pedro Baptista, Patricia Carvalho and Eulalia Pereira,
Universidade Nova de Lisboa, Universidade do Porto and Universidade Techica de Lisboa
Monodisperse magnetic nanoparticles were produced and subsequently coated with a gold layer by the reduction at surface of a gold precursor in order to develop an integrated detection and “gene fishing” system. Functionalization of the nanoparticles could allow the application of this system to a variety of biomolecules.
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Intravenous Geletin Nanoparticulate Formation of Vincristine Sulfate: Preparation, Characterisation and Release Studies
Akanksha Chauhan, V.S Shenoy and R.S.R Murthy,
The Maharaja University of Baroda
Gelatin could be used as a carrier to prepare nanoparticles with considerable entrapment of Vincristine sulfate. The prepair nanoparticles could release over a period of time. The in vitro release studies have been encouraging and a possible reduction of toxicities of Vincristine sulfate would be expected on further in vivo studies.
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